Synapse Specificity and Long-Term Information Storage

Synapse Specificity and Long-Term Information Storage

would enable them to coopt proteins destined for other The dendrites of a typical neuron in the central nervous late LTP synaptic sites. To test this idea, a “two-pathsystem bear at least 1000 postsynaptic specializations way” experimental design was employed in which two indicating that in principal the individual neuron can independent sets of presynaptic afferents that converge process and s...

Mechanisms for synapse specificity during striatal long-term depression.

Endocannabinoid (eCB)-mediated forms of long-term synaptic plasticity occur in several brain regions, but much remains unknown about their basic properties and underlying mechanisms. Here, we present evidence that eCB-mediated long-term depression (eCB-LTD) at excitatory synapses on medium spiny neurons in the striatum requires presynaptic activity coincident with CB1 receptor activation. This ...

Synapse specificity of long-term potentiation breaks down with aging.

Memory shows age-related decline. According to the current prevailing theoretical model, encoding of memories relies on modifications in the strength of the synapses connecting the different cells within a neuronal network. The selective increases in synaptic weight are thought to be biologically implemented by long-term potentiation (LTP). Here, we report that tetanic stimulation of afferent f...

Single Transistor Learning Synapse with Long Term Storage

We describe the design, fabrication, characterization, and modeling of an array of single transistor synapses. The single transistor synapses simultaneously perform long term weight storage, compute the product of the input and oating gate value, and update the weight value according to a hebbian or a backpropagation learning rule. The charge on the oating gate is decreased by hot electron inje...

NMDA Receptor-Dependent Long-Term Potentiation and Long-Term Subject Collection The Synapse Synapses and Memory Storage Kandel